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The Wyatt Lab

What We Do

Our overarching goal is to understand how human cells execute accurate DNA repair and maintain chromosome stability. The physiological significance of our research is underscored by the fact that defects in DNA repair and/or genome stability give rise to several deleterious diseases, including cancer. We use a powerful combination of in vitro and in vivo approaches and technologies to address our questions. Learn more about our research & experimental approaches below.

Research

Unlocking the Mysteries of DNA Nucleases in Genome Stability

We are interested in studying how the potentially damaging power of DNA nucleases is directed to safeguard genome integrity. Our long-term goal is to understand how human cells execute accurate DNA repair, a major barrier to the development of cancer.

 

You can find out more about our current research projects by clicking the link below.

Experimental Approaches

We use a powerful combination of complementary techniques in biochemistry and molecular biology to address our research questions.

Click on the images below to learn more.

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Biochemistry

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Molecular Biology

Contact Us

Thanks for your interest in our research. Get in touch with us for any questions or comments regarding our work. Individuals interested in joining the lab should check out the Available Positions page for more information.

University of Toronto, Department of Biochemistry

MaRS Center, West Tower, Room 1521A

661 University Avenue

Toronto, Ontario

M5G 1M1

1-416-978-4808 (office), 1-416-946-3440 (lab)

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