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The Wyatt Lab

What We Do

Our overarching goal is to understand how human cells execute accurate DNA repair and maintain chromosome stability. The physiological significance of our research is underscored by the fact that defects in DNA repair and/or genome stability give rise to several deleterious diseases, including cancer. We use a powerful combination of in vitro and in vivo approaches and technologies to address our questions. Learn more about our research & experimental approaches below.

Pipetting Samples and Test Tube
Pipetting Samples
Test Tubes


Unlocking the Mysteries of DNA Nucleases in Genome Stability

We are interested in studying how the potentially damaging power of DNA nucleases is directed to safeguard genome integrity. Our long-term goal is to understand how human cells execute accurate DNA repair, a major barrier to the development of cancer.


You can find out more about our current research projects by clicking the link below.

Experimental Approaches

We use a powerful combination of complementary techniques in biochemistry and molecular biology to address our research questions.

Click on the images below to learn more.




Molecular Biology

Statement on Equity, Diversity,
and Excellence

The Wyatt lab is strongly committed to equity, diversity and inclusion, as stated in the University of Toronto's Statement of Equity, Diversity and Excellence, excerpted below.

"At the University of Toronto, we strive to be an equitable and inclusive community, rich with diversity, protecting the human rights of all persons, and based upon understanding and mutual respect for the dignity and worth of every person. We seek to ensure to the greatest extent possible that all students and employees enjoy the opportunity to participate as they see fit in the full range of activities that the University offers, and to achieve their full potential as members of the University community.
We will proactively seek to increase diversity among our community members, and it is our aim to have a student body and teaching and administrative staffs that mirror the diversity of the pool of potential qualified applicants for those positions.
We believe that excellence flourishes in an environment that embraces the broadest range of people, that helps them to achieve their full potential, that facilitates the free expression of their diverse perspectives through respectful discourse, and in which high standards are maintained for students and staff alike. An equitable and inclusive working and learning environment creates the conditions for our diverse staff and student body to maximize their creativity and their contributions, thereby supporting excellence in all dimensions

of the institution."

Contact Us

Thanks for your interest in our research. Get in touch with us for any questions or comments regarding our work. Individuals interested in joining the lab should check out the Available Positions page for more information.

University of Toronto, Department of Biochemistry

MaRS Center, West Tower, Room 1521A

661 University Avenue

Toronto, Ontario

M5G 1M1

1-416-978-4808 (office), 1-416-946-3440 (lab)

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